NAD+

NAD+, or Nicotinamide adenine dinucleotide, is a fundamental coenzyme derived from Niacin or Vitamin B3, and it resides naturally in every cell of all living organisms. It plays a pivotal role in more than 100 metabolic activities, the primary of which is energy production, critical for regular functioning and wellbeing.

A crucial function of NAD+ lies in the Krebs cycle, also known as the citric acid cycle, where it acts as a key facilitator for energy generation. In this process, NAD+ transfers electrons and hydrogen, reacting with oxygen in the mitochondria to generate ATP, the energy currency of cells. This conversion helps transfer energy from consumed food to vital cellular functions.

NAD+ is also a vital cofactor for longevity-promoting enzymes known as sirtuins, specifically SIRT1 and SIRT3, which control gene expression and are closely associated with lifespan extension. These enzymes are activated under calorie restriction scenarios and work to extend lifespan by boosting NAD levels. Compounds like resveratrol and pterostilbene stimulate SIRT1 and SIRT3, and deactivate genes promoting aging, such as those leading to inflammation, fat synthesis, storage, and blood sugar level regulation.

However, with aging and certain mental health disorders, NAD+ levels tend to decline, affecting cellular functions and overall health. The aging process typically brings about an increase in fatigue and a loss of motivation, reflecting an internal impairment of vital cellular functions due to NAD deficiency. The NAD+/NADH ratio, which oscillates continuously during the mitochondrial metabolic process, regulates various enzymes involved in different metabolic pathways. Despite NAD+'s role as a potent antioxidant, its levels tend to decrease with age, which negatively impacts both physical and mental wellness. Therefore, augmenting NAD+ levels can contribute to a return to a healthier state.

NAD+ plays several essential roles in maintaining overall health and optimal cellular function. It facilitates cell replication, protection, and repair, and boosts neurotransmitter production, thereby improving memory, focus, and mood. Moreover, NAD+ helps in efficient nutrient utilization within cells and aids in detoxification processes, especially in eliminating brain waste that can interfere with neurotransmitters.

It enhances the production of Nitric Oxide (NO), which improves blood flow and blood pressure, and strengthens the integrity of vascular endothelial tissues. Additionally, NAD+ reverses insulin resistance and aids in swift blood glucose regulation.

Serving as a potent antioxidant and anti-inflammatory agent, NAD+ is especially crucial for the brain, which utilizes NAD+ for energy ten times more than other tissues. It performs critical neuroprotective functions, boosts metabolism, and can aid in weight loss.

NAD+ also prevents mitochondrial decay, a primary aging factor, thus contributing significantly to longevity and healthy aging. In summary, NAD+ is an integral coenzyme that supports a myriad of bodily functions, contributing to improved brain function, metabolic health, and anti-aging processes.

• Neurotransmitter Deficiency - Memory impairment, lack of focus and concentration
• Reduction in SIRT1 and SIRT3 leading to acceleration of aging process.
• Mitochondrial dysfunction and eventual cellular death.
• Chronic fatigue.
• Weakened immune system - leading to infections and cancer.
• Alcohol and drug addiction.
• Muscle weakness and pain - fatty deposition in muscle tissue.
• Increased fat storage in liver and adipose tissue.
• Headaches, insomnia.
• Lack of ambition, apathy.
• Mood and anxiety disorders.

NAD+ deficiency can occur due to several reasons:

1. Aging: As part of the natural aging process, NAD+ levels in the body decline. This is one of the most common reasons for NAD+ deficiency. With time, the body's ability to produce and recycle NAD+ reduces, leading to lower overall levels of the coenzyme.
2. Unhealthy Lifestyle Choices: Factors like a poor diet, lack of exercise, excessive alcohol consumption, and smoking can all lead to a decrease in NAD+ levels. These unhealthy habits can increase oxidative stress and inflammation in the body, which in turn consumes more NAD+, causing its levels to decrease.
3. Chronic Health Conditions: Certain chronic conditions like obesity, type 2 diabetes, heart disease, and neurodegenerative diseases can also lead to a decline in NAD+ levels. These conditions often involve increased oxidative stress or inflammation, both of which can consume NAD+ and lead to a deficiency.
4. Genetic Factors: Some people may have genetic factors that affect the body's ability to produce or utilize NAD+. Certain gene mutations can impact the enzymes involved in NAD+ biosynthesis or consumption, leading to a deficiency.
5. Certain Medications and Treatments: Some medications, particularly those used in chemotherapy, can reduce NAD+ levels in the body. This is because these treatments can cause damage to healthy cells and deplete NAD+ as the body tries to repair this damage.
6. Environmental Stressors: Exposure to environmental stressors such as radiation, toxins, or chronic stress can also lead to a decrease in NAD+ levels. These stressors can increase the body's demand for NAD+ as it attempts to repair damage and cope with the stress, leading to potential deficiency.

In conclusion, NAD+ deficiency can result from a combination of lifestyle factors, health conditions, genetics, certain treatments, and exposure to environmental stressors. It's important to understand these factors as maintaining optimal NAD+ levels plays a crucial role in various bodily functions and overall health.

The benefits of NAD+ supplementation are multi-faceted. Primarily, it results in enhanced energy, improved mood, better sleep, and reduced stress and anxiety. These benefits can ameliorate symptoms of PTSD and depression. Physical benefits include boosted immunity, hydration, improved recovery from exercise, and the enhanced health of hair, nails, and skin. NAD+ infusions can also slow down the aging process, making it a significant development in anti-aging medicine.

By contributing to brain health and combating chronic fatigue, NAD+ infusions amplify energy levels, accelerate metabolism, promote healthy cell regeneration, and facilitate the repair of damaged DNA. These infusions can also reduce inflammation within the body, mitigate cognitive decline, and further decelerate the aging process.

NAD+ IV therapy is particularly beneficial for those experiencing reduced energy levels, chronic fatigue, or persistent mental fog, as well as those grappling with the side effects of aging, age-related illnesses, or chronic conditions. However, it is also advantageous for healthy individuals, including athletes seeking to enhance their performance and recovery following strenuous exercise or injury.

This therapy has shown promise for individuals dealing with conditions like Alzheimer’s disease, Parkinson’s disease, heart disease, diabetes, mitochondrial dysfunction, multiple sclerosis, fibromyalgia, and anxiety or depression. It can also help those facing memory and concentration challenges. Even healthy individuals may benefit from IV supplementation to help delay the aging process and minimize the risk of certain medical conditions.

Furthermore, NAD+ infusions could potentially benefit those battling substance addictions, as they can repair brain cells damaged by substance abuse and regenerate opiate receptors, thus decreasing cravings and withdrawal symptoms.

NAD+ plays a crucial role in various biological processes including DNA repair and protection, regulation of gene expression, energy extraction from nutrients, preservation of mitochondrial function, maintenance of chromosomal integrity, calcium signaling facilitation, and implementation of epigenetic and post-translational modifications.

As we age, our bodies produce less of this essential coenzyme, leading to physical signs of aging and increased susceptibility to age-related diseases. Intravenous (IV) therapy can supplement NAD+ levels in the body, helping combat the effects of aging and disease, promoting a healthier and more youthful feeling.

The administration of NAD+ through Intravenous (IV) therapy is an advantageous method of replenishing this vital coenzyme in your body. IV therapy works by infusing vitamins and supplements directly into your bloodstream, thus enhancing your overall wellbeing and promoting specific health benefits. NAD+ delivered via an IV drip allows for 100% bioavailability, which means your body is able to absorb and convert the maximum possible amount of this coenzyme into cellular energy.

Oral NAD+ supplements are available, but the human body can struggle with absorbing NAD+ in this form. The process of digestion may reduce the bioavailability of the coenzyme, making it harder for the body to fully utilize it. This presents a challenge in terms of guaranteeing the effectiveness of oral NAD+ supplements.

Presently, IV therapy is deemed as the safest and most efficient means of boosting the levels of NAD+ in your body. It sidesteps the digestive system, facilitating the full absorption and utility of the administered coenzyme. Therefore, NAD+ IV infusions are particularly recommended for individuals seeking a smoother aging process, preparing for detoxification, or managing mental health issues.

In conclusion, while oral NAD+ supplements are an available option, they often fall short in effectiveness when compared to IV infusions. This is primarily due to the challenges in absorption posed by the digestive system. Hence, IV therapy remains the preferred and most effective method for restoring your body's NAD+ levels. Over-the-counter supplements simply don't measure up in terms of yielding the benefits of this potent coenzyme, as the digestion process can substantially reduce their efficacy.

NAD+ plays a pivotal role in the body's healing processes, and its deficiency can lead to complications such as a slowdown in metabolism, cognitive difficulties, and a weakened immune system. NAD+ infusions can help mitigate these issues by replenishing the body's NAD+ levels, and it also offers neuron protection against neurodegenerative diseases.

Our anti-aging treatment comprises weekly NAD+ infusions designed to slow down the aging process and rejuvenate energy and wellbeing. NAD+ combats aging by restoring the functionality of vital life-sustaining processes at the cellular level. It is integral for cellular regeneration, switching off aging-related genes, and playing a critical role in DNA repair and the maintenance of telomeres, which protect our chromosomes. Moreover, NAD+ protects brain cells, performs essential cell signaling functions, and activates enzymes known as Sirtuins, which slow the aging process. It also restores mitochondrial functionality, mitigates oxidative stress, and serves as an anti-inflammatory agent. In this way, NAD+ infusions can contribute significantly to healthier aging.

NAD+ plays a significant role in maintaining mental health and facilitating recovery. It protects neurons, enhances cognitive functions and mental clarity, and helps combat stress, fatigue, exhaustion, and motivational deficits. It's particularly beneficial for individuals struggling with substance abuse, as it can ease cravings and discomfort during detoxification.

As for how NAD+ infusions improve brain health, many people report a notable reduction in mental fog following NAD+ therapy. This improvement in mental sharpness can enhance everyday experiences and overall well-being. A common sign of aging is a decline in cognitive function, which can manifest as forgetfulness, lack of focus, and a general sense of mental haziness.

Through an NAD+ IV infusion, neuronal function in the brain can be stimulated, promoting cell regeneration and protection against damage. This leads to an enhancement in cognitive abilities, including increased mental clarity, heightened focus, and improved memory function.

This marked improvement in brain function can aid individuals in overcoming various mental challenges. IV therapy can provide support in battling common conditions such as depression, anxiety, and mood disorders.

During the infusion process, NAD+ can sometimes cause side effects such as nausea, brain fog, cramping, and muscle fatigue. These effects are typically linked to the speed of the IV drip, and can be easily managed by reducing the infusion rate.

If you encounter any of these symptoms during your treatment, notify us and we will adjust your drip rate. If symptoms are severe, we may temporarily stop your infusion and restart after they subside.

Eating leafy greens before the infusion and snacking on berries during the process may enhance some individuals' tolerance to the treatment. Additionally, medications such as ondansetron (Zofran) or ketorolac (Toradol) may help manage side effects. Lastly, initiating the infusion at a slow rate and gradually increasing it over the first 30 minutes could also help mitigate potential discomfort.

After an NAD+ infusion, most people experience a variety of immediate and long-term effects, though these can vary from person to person based on individual health conditions and the specific reasons for undergoing the treatment. Aside from local tenderness at the infusion or injection site, here are some common effects you might expect:

Immediate Effects:

1. Increased Energy: One of the most immediate effects of NAD+ therapy is an increase in energy, similar to the feeling after a good night's sleep or a restorative nap.
2. Enhanced Mood: Many individuals report feeling a mood elevation, experiencing reduced anxiety or depression, and an overall improvement in their emotional wellbeing.
3. Clarity and Focus: NAD+ can boost cognitive function, leading to improved mental clarity, increased focus, and better problem-solving skills.
4. Reduced Withdrawal Symptoms: For people undergoing detoxification for substance abuse, NAD+ therapy can reduce cravings and withdrawal symptoms.

Long-Term Effects:

1. Improved Sleep Patterns: Over time, you may notice better sleep quality and patterns, which can have a positive impact on your overall health and daily functioning.
2. Better Physical Health: NAD+ infusions can support improved physical performance and recovery. This can manifest as better workouts, faster recovery times, and increased endurance.
3. Improved Brain Health: NAD+ therapy may contribute to long-term improvements in brain health, potentially reducing the risk of neurodegenerative diseases and improving memory and concentration.
4. Slow Aging: NAD+ plays a key role in anti-aging, and consistent therapy can help slow the aging process, leading to better skin health, reduced inflammation, and a slower onset of age-related diseases.
5. Regulated Metabolism: NAD+ infusions can improve metabolic function, aiding in weight management and overall health.
6. Improved Chronic Conditions: Over time, NAD+ can help improve certain chronic conditions such as fibromyalgia, chronic fatigue syndrome, and depression.

It's important to note that while some individuals may feel an immediate boost post-infusion, others may not notice significant changes immediately. However, this doesn't mean the infusion isn't working. Long-term benefits are often observed over a period of days to weeks following treatment.

NAD+ infusion therapy is an entirely safe therapeutic option. It utilizes a natural substance that the body readily accepts.
Baseline labs are recommended if available or feasible to help screen for underlying conditions such as renal disease. However, in the absence of significant comorbidities NAD+ treatment is safe and well tolerated.

All patients should start with a low test dose to check for tolerance.

Yes.

1. Known allergy or hypersensitivity to NAD+ or related compounds, to include symptoms such as rash, itching, swelling, difficulty breathing, or other severe symptoms.
2. Pregnancy and breastfeeding: Although NAD+ is depleted in both of these circumstances, effects are unknown so best to avoid.
3. Acute liver or kidney disease.
4. Certain medications including antiplatelet and anticoagulant medications, diabetes medications such as insulin or oral hypoglycemic agents, chemotherapy, immunosuppressant medications, psychiatric medications such as SSRIs and tricyclic antidepressants.
5. Also, patients with a history of cancer or who currently have cancer may want to discuss NAD+ therapy with their oncologist as it may potentially stimulate the growth of certain cancers

Nicotinamide or Vitamin B3 can be measured directly. This testing is not approved by the FDA and reference ranges have not been established. There are some dried blood spot kits for NAD+ measurements on the market. There is a complex relationship between NAD+ and uric acid levels. Some believe that low uric acid levels indicate an NAD+ deficiency. Because there is no reliable gold standard of testing, it is recommended to base decisions on subjective symptoms and clinical outcomes.

1. The process starts with a free consult to determine if you are likely to benefit and assess potential safety concerns. This consult can be in person, video or telephone.
2. After your free consult, you will complete a medical history for our clinician to review. If cleared for therapy, our clinician will make dose and frequency recommendations based on your goals.
3. You will then schedule an initial infusion of 250mg. This dose tests for tolerance and takes about two hours. You may then proceed with 500mg infusions or lower dose home injections or both. We recommend a combination of NAD+ infusions, vitamin infusions and home injections. If distance, other challenges or simply preference, we do offer a home self-injection program as a stand alone option. Because of dosing limitations, it is still recommended to obtain full dose infusions at least monthly to saturate cells.
4. The 250mg dose takes about 2hours and the 500mg dose takes about 4hours.
5. If you are short on time, but want a boost, you can opt for a 50-100mg injection. You are eligible for the higher dose only after you have received and tolerated the 50mg injection. Also, if you receive the 100mg injection, you will need to stay in the clinic for a minimum of 10minutes prior to driving. This higher dose can cause you to feel woozy temporarily while it enters your circulation and absorbs into your cells.

• Initially, frequent infusions are recommended to boost your system and saturate your cells. We also recommend a vitamin infusion, called a “Myers” right before your NAD+ infusion. This “sets the table” to ensure your cells and mitochondria have the components needed to maximize the benefits of your NAD+ infusion. If you are doing injections, a monthly infusion of both NAD+ and Myers is recommended at a minimum.
• Dosing starts with a 250mg test dose. After that, you may continue with 250mg or increase to 500mg dosing. Most people receive the 500mg dose, but this can be challenging due to time
• The 250mg dose takes about 2hours and the 500mg dose takes about 4hours. Higher dosing is reserved for specialty conditions, like addiction.
• If you are short on time or money, but want a boost, you can opt for a 50-100mg injection. You are eligible for the higher dose only after you have received and tolerated the 50mg injection. Also, if you receive the 100mg injection, you will need to stay in the clinic for a minimum of 10minutes prior to driving. This higher dose can cause you to feel woozy temporarily while it enters your circulation and absorbs into your cells.

• There are no special preparation requirements.
• However, it is recommended that you have a light meal or snack prior to your infusion. This helps with the potential nausea.
• We also recommend that you arrive moderately hydrated to improve venous accessibility.

Activities are as tolerated, but extreme weight lifting should be avoided. This may cause your IV site to start bleeding again.