nad-therapy
Injections & Infusions, Peptides

10+1 Benefits You Need to Know About NAD+ for anti aging

nad-therapy

Do you want to slow down your body’s aging process and boost your youthful energy?

Nicotinamide Adenine Dinucleotide (NAD+) naturally occurs as a cellular compound in the body, which is vital to life. It aids in the efficient transport of energy from the food you eat into the cells of your body.


NAD+ has two precursors, namely nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). The latter is a new generation B3 vitamin that boosts NAD+ of your body’s metabolic factor.


NAD+ restores your cell’s youthful function as it turns off genes that speed up the aging processes. It also promotes the repair of your DNA, protects your tissues, and thus prolongs your lifespan.


A pharmacologic review was conducted to determine drugs that help improve or delay aging. The result of the study reveals NAD+ precursors as a promising anti-aging drug. It may improve your organ function and strengthen your resistance against diseases, too.


NAD+ comes in various forms. One of the more convenient ways is an NAD+ patch. It’s available at the Injection and Infusion Clinic of ABQ.


Watch a video of Nurse Practitioner, Katherine Devine, as she demonstrates how the NAD+ patch is used. While the patch is convenient, it is less effective than an infusion and can cause local irritation. The preferred route is dependent on your individual response.

Discover the 10+1 benefits of NAD+

Builds your body’s resiliency and protects you from stress.

Have you been feeling sluggish lately? Low levels of NAD+ have this effect since your body has reduced the production of cell energy.

Boosting your NAD+ with NR promotes vigor and increases endurance since it prevents the decline of cell energy.

  • NAD+ levels decline as you age, which causes changes in your metabolism. It also increases your risk of developing diseases. Based on a 2019 study, restoring NAD+ levels promoted health and extended lifespan.
     
  • As a form of vitamin B3, oral intake of NR a precursor of NAD+ boosted the NAD+ levels in mice. This effectively delayed late-stage disease progression by inducing mitochondrial regrowth (Khan et al., 2014).
     
  • NAD+ depletion may be due to genotoxic stress. It’s when the genetic information in a cell is damaged which can lead to cancer. The researchers observed an increase of Nampt and mitochondrial NAD+ in rodents after 48 hours of fasting.
     
  • Nampt is an NAD+ biosynthetic enzyme. Increased Nampt serves to protect against cell death and mitochondrial NAD+ levels that impact cell survival.

Extends your lifespan.

Researchers explained that reduced NAD uptake is related to many physical aging processes. NAD precursors such as NMN and NR protect the body against aging-related diseases.

The researchers further noted that boosting NAD metabolism can extend lifespan. NAD+ has also emerged as a factor in enhancing oxidative metabolism that promotes healthy aging and extended the life span of worms.


NAD+ intermediates NMN and NR can boost the system by restoring NAD+ and lessen physical symptoms of aging. This supports the new studies that NAD+ intermediates can be a promising and effective anti-aging therapy.

NAD+ activates a key enzyme called sirtuins which regulates genes of aging. Activated sirtuins with NAD+ supplementation may be an intervention for anti-aging.


Sirtuins turn off certain genes that contribute to aging. These are the management of blood sugar, fat storage and synthesis, and inflammation (Kotas et al., 2013).

Improves your cognitive function

NAD+ reduces oxidative cell damage in the brain. It can be a promising therapeutic strategy for age-related degenerative diseases, which can be further customized based on a person’s condition. An example is Alzheimer’s disease.

In a study, NR exhibited the ability to protect brain cells among old-age mice. The 5-6-month-old mice were made to develop Alzheimer’s disease. They were then given NR until they reached 10-11 months.

Through a laboratory test, the researchers discovered NR may have improved the cognitive function of the mice.

NAD+ with sirtuin activation counteracts the progression of neurodegenerative diseases and it may also be an effective anti-aging intervention.


Reduces your cravings for food, drugs, and alcohol

A study shows that addiction to food undergoes the same process as addiction to drugs and alcoho.

NAD+ helps with food, drugs, and alcohol problems through its mechanism of action. It has been shown to initiate cellular repair and regeneration in neuropsychiatric conditions such as addiction.

A study further reveals the significance of NAD+ in these addictive disorders. The researcher claimed that intravenous NAD+ treated over 104 people addicted to alcohol and various drugs.

NAD+ also completely removed the addictive symptoms. Thus, NAD+ may flush addictive substances in your system, curb your cravings, and reduce your withdrawal symptoms.

Suppresses your weight gain associated with aging

Food addiction has been linked to obesity. NAD+ may help with your food addiction and it may also maintain your weight as you age.

Researchers experimented on mice in a 12-month study. The mice were given oral NMN which synthesized NAD+ in the tissues.

The results show that it curbed age-associated increase in weight and improved insulin levels and plasma lipid.

The researchers also noted enhanced energy uptake and promoted physical activity.
NR the precursor of NDA+ boosts oxidative metabolism and protects against obesity brought about by a high-fat diet.

Mice were given NR in the test, which showed an increase in their muscle endurance. The mice also exhibited improved performance.

Thus, NR as a natural vitamin could be a nutritional supplement to address age-related and metabolic disorders indicated by mitochondrial breakdown (Canitó et al., 2013).

Potential therapeutic agent for diabetes

NMN, as an intermediate of NAD+ could be a potential therapeutic agent for diabetes, Alzheimer’s, and cardiovascular disease.

An earlier study conducted by researchers of the Washington State University School of Medicine supports this claim.

The diabetic mice received NMN supplements. The researchers restored the normal blood sugar metabolism, which suggested NMN as a potential prevention and treatment of type 2 diabetes.

Potential therapeutic agent for heart disease

Researchers in a mice test concluded that NAD+ boosters and sirtuin activators with its mRNA-regulated anti-aging mechanisms have the potential to prevent and treat vascular diseases associated with aging.

Evidence suggests that boosting NAD+ levels promoted an increase in blood flow and the growth of new blood vessels. This protects against age-related enlargement or thickening of the walls of the heart.

Potential therapeutic agent for cancer

Other than preventing neurodegeneration and metabolic dysfunction, keeping NAD+ at optimum levels may be important in preventing cancer formationIt may prevent and treat liver cancer, and aging-related tumors.

Makes you sleep better

NAD+ resets the body’s internal clock due to its effect on the circadian rhythm. The sleep-wake cycle depends on the body’s reaction to light and dark. This signals you when to wake up or sleep or feel hungry.

Maintaining the sirtuins or NAD+ levels is ideal for the circadian rhythm. Thus, NAD+ may promote better sleep.

Improves your muscle health

A recent study was conducted to investigate the effects of increasing NAD+ levels on metabolic health. The researchers gave NR supplements to 113 overweight or obese participants.

After six weeks, the results reveal that the participants increased skeletal muscle and lean mass. The participants also decreased fat mass.

Enhances your mood

Researchers studied the effects of increasing NAD+ with NR supplements to the brain and gut microbiota. Mice with alcohol-induced depression served as test subjects.

The researchers noted an improvement in the behavior of the mice. Moreover, NR decreased inflammation in the mice’s brain.

This indicates NR as a potential anti-inflammatory. The inflammation of the brain has been associated with psychological and mood disorders, such as depression.

Is NAD+ safe?

A study found out that continuing supplementation of NAD+ precursor vitamin, NR is well-tolerated and effectively stimulated NAD+ metabolism in healthy and older adults.

It’s been studied as safe, well-tolerated, and efficiently increase NAD levels in healthy people, too. To improve NAD metabolism, it was suggested as a practical topic for nutritional intervention.

NR is non-irritating to the skin and it won’t cause the flush associated with niacin, a common form of vitamin B3. One hundred and forty healthy people participated in an 8-week study.

This study investigated the efficacy and safety of oral supplements of NR on NAD+. Participants who had NR, termed Niagen, reported no flushing.


The study also reveals that NR did not increase low-density lipoprotein or bad cholesterol.

Best way to have your NAD+

There’s a natural way to boost your NAD+ level. That’s from the food you eat. NAD+ rich foods include salmon, sardines, and mushrooms. Or NAD+ can be taken in three ways.


1. You can drink it as a supplement, put it on your skin as a cream or patch, or as an infusion. The challenge with oral supplements is absorption and bioavailability. It is also the least effective among the other forms.

nad infusion

2. Infusions are the most bioavailable. They can be time-intensive with the standard 500mg dose taking 3-4hours.

nad+

3. A more affordable and easy way is a patch. The effect lasts up to three days. How hard could it be?

Here’s a video of ABQ Business podcast host, Jason Rigby on his NAD+ patch do-it-yourself experience:

To know the best option for your NAD+ booster, visit us at the Infusion and Injection Clinic of ABQ at 8400 Osuna Road NE, Suite 5C
Albuquerque, NM 87111 or call us at 505 445 4300.

We offer both a NAD patch and infusion. We recommend the infusion for the most impact, but do find the patch to be a possible adjunct to regular infusions.

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what is ghk-cu
Aesthetics, Peptides

What is the GHK-Cu Peptide? Benefits and Applications

what is ghk-cu

What is GHK-Cu?

Everyone wants to look young, but few know about the compound GHK-Cu. It’s regarded as high-interest in the scientific community, due to its regenerative properties. And as you’ll soon find out, GHK-Cu may just be the key ingredient to everlasting youth.

GHK stands for the amino acids glycyl-L-histidyl-L-lysine. It’s a small, naturally-occurring peptide that binds to copper. In the presence of injury, our body produces this compound to accelerate healing and regeneration.

GHK-Cu is present in collagen, the main structural protein of connective tissues in the body. One early study described its role in skin repair. Researchers discovered that GHK promotes the production of cells that make up the extracellular matrix.


These cells consist of collagen, as well as glycosaminoglycans and decorin. Glycosaminoglycans prevent the accumulation of damaged proteins and excessive protein breakdown in the site of tissue injuries.

Besides being a miracle that can reverse aging, it is also known as a gene regulator. On a molecular level, it interacts with specific types of genes and can either activate or deactivate them. As a result, it’s no surprise that it has been studied extensively across laboratories worldwide.

As of today, GHK-Cu has been associated with the following properties:

  • Makes skin more smooth, firm, and clear
  • Decreases depth of wrinkles and reduces fine lines
  • Decreases skin spots and hyperpigmentations
  • Promotes wound healing
  • Protects the skin from the sun
  • Anti-inflammatory
  • Promotes hair growth

Peptides for Skin and Hair

One peptide combo even has a botox-like effect! While there are many products available, the Injection & Infusion Clinic of ABQ has focused on the most effective!

If GHK-Cu is something our body naturally produces then why do we still develop wrinkles and fine lines? Why do we still have skin spots and why do we still need sunscreen for UV protection?

The answer to this question is the same problem scientists have spent years trying to solve: age. Children and young adults have especially high GHK-Cu levels. However, as we get older, our GHK-Cu levels decrease.

To put things into perspective, someone at 20 years of age would have approximately 200ng/mL of GHK-Cu. At 60 years of age, this amount goes down to 80ng/mL. As a result, our skin loses its firmness and elasticity as we mature.

medical applications

Cosmetic Application of GHK-Cu

Fibroblasts are cells that produce the extracellular matrix, which make up the main component of connective tissues. The ability of GHK-Cu to modulate collagen synthesis in fibroblasts makes it an ideal component for many skin and hair products.

Even without copper, GHK can increase the number of keratinocytes, which are cells found in the outermost layer of our skin. Additionally, GHK can also
increase the expression of integrin - a protein that strengthens cell adhesion.

In one study, a group of women used a facial cream with GHK-Cu for 12 weeks. After the 12 week timeframe, the participants had firmer skin with less fine lines. The depth of their wrinkles decreased, and the overall clarity of their skin improved.

Besides being used in facial creams, it is also effective as eye cream. In another study, 41 women used a GHK-Cu eye cream for 12 weeks.

Compared to the group that used a placebo containing Vitamin K, the participants that used GHK-Cu eye cream around their eyes had less wrinkles and fine lines. The density and thickness of their skin also improved.

Products that contain GHK-Cu can also improve skin hydration and skin elasticity. Some studies made use of GHK-Cu encapsulated in nano-lipid carriers. Women that applied these products throughout the span of 8 weeks had 31.6% reduction in wrinkle volume, compared to groups that used a different product.

In hair products, GHK-Cu can improve hair follicle size. It is also known to improve hair transplant success because of its role in fibroblast and keratinocyte proliferation.

Peptides for Skin and Hair

GHK-Cu stimulates collagen and increases skin thickness, which decreases fine lines and supports sagging skin. Contact us at 505-445-4300 to order!

ghk cu the injection and infusion clinic of abq

GHK-Cu can Improve
Wound Healing

Your body has a natural way of healing itself over time. However, this healing process does not occur unless there is an inflammatory response, such as a tissue injury. As a result, the skin or tissue that results afterwards may appear different, as in the case with scars.


GHK-Cu helps our body to heal faster, by attracting macrophages and mast cells to repair the area of injury. This reduces the amount of free radicals produced in the inflammatory process, which can improve the formation of granular tissue.


GHK-Cu also increases the production of factors that promote blood and nerve vessel growth. Large volumes of blood are an essential component in speeding up the healing process. This is because blood provides the nutrients and oxygen needed by our cells.


As GHK is a gene regulator, it can also inhibit blood vessel growth in the latter parts of the healing process. Without this inhibition, healed skin tissue would be more sensitive to stimuli than usual. This is also why adequately healed skin tissue often lacks sensation. As well, studies have shown that GHK can also promote the growth of nerve cells.

Multiple studies on animals have demonstrated the wound healing properties of GHK-Cu. In scald wounds of mice, administration of GHK-Cu liposomes resulted in better angiogenesis - or blood vessel growth. After application of GHK-Cu, these scalp wounds healed after a minimum of 14 days with minimal scarring.

In thick open wounds of rabbits, application of GHK-Cu resulted in faster reduction of wound size compared to application of zinc oxide and no treatment groups. Researchers noted that neovascularization - or blood vessel growth, performed better for the rabbits in the GHK-Cu group. They correlate this outcome to shorter healing time.

injection-&-infusion-clinic-of-abq-ghk-cu-medical-applications

Other Medical Applications

*Unfortunately in 2020, the FDA severely restricted/eliminated the ability to obtain GHK-Cu injectable. Therefore, non-topical applications are not currently accessible.

1

Acute Lung Injury

Acute lung injury - or ALI, is characterized by severe inflammation that results in tissue injury. If it progresses, ALI can become acute respiratory distress syndrome, which is characterized by hypoxemia, lung edema and difficulty breathing.

Before the COVID-19 pandemic, the incidence of ALI was 1.5 to 100 per 100,000 person-years (Park et al, 2016). Presently, the prevalence of acute lung injury in severe COVID-19 infectees is 30%. Studies have shown the occurrence of ALI can predict the prognosis of a patient (Li et al., 2020).

The role of GHK-Cu in acute lung injury has only been studied on animals; however, the results are promising. ALI is caused by excessive neutrophil infiltration in the lungs, and GHK-Cu has been found to counteract this harmful effect. In a similar study performed on mice, researchers discovered that GHK-Cu can reduce TNF-α and IL-6 expression, which are both involved with an inflammatory reaction in the lungs (Park et al, 2016).

These early studies give researchers hope. The discovery of these outcomes provides the groundwork for future treatments involving acute lung injury, and acute respiratory distress syndrome.

2

Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease - or COPD, is a chronic lung disease characterized by bronchitis or airway inflammation, emphysema and asthma. It is a lifelong illness that requires maintenance medications to decrease the frequency of attacks. 

GHK-Cu is a gene regulator that influences the expression of several genes in the human genome. Recent literature has discovered that GHK-Cu can affect the expression of 127 genes in COPD patients. Excessive expression of certain genes can also increase inflammation in COPD, while decreasing the expression of genes that are responsible for repair. GHK-Cu was postulated to reverse this gene expression pattern found in COPD patients, by activating a different pathway. 

Researchers have also performed in vitro experiments with positive results. GHK was added to the lung fibroblasts of COPD patients with impaired repair mechanisms. After treatment with GHK, this function was restored (Pickart & Margolina, 2018).

2

Cardiovascular Diseases

Fibrinogen is a protein manufactured by the liver. In the presence of tissue injury, it forms a clot to stop bleeding. However, too much fibrinogen can also be a bad thing, as it makes blood more viscous and prone to clotting. This results in an increased risk of cardiovascular complications like heart attacks and strokes. 

GHK has also been shown to suppress IL-6, a protein regulator needed for the production of fibrinogen. This experiment was observed in vitro and in vivo in mice. Overall, outcomes conclude that GHK can suppress the production of too much fibrinogen. (Pickart & Margolina, 2018).

2

Cancer

Any compound that increases cell growth also has the potential to become cancerous - except GHK-Cu. In 2010, researchers explored the anti-cancer properties of over 1000 bioactive molecules. Only 2 substances were able to suppress the metastatic genes; one of these was GHK.

On top of not having cancer-related symptoms, GHK can downregulate RNA synthesis in patients with cancer. 70% of genes that are overexpressed have been shown to return to normal after treatment. Based on these outcomes, it appears that GHK isn’t just randomly suppressing and upregulating genes. In fact, it may actually reset the activity of these specific genes, allowing them to act the way they’re supposed to.

More specific studies explored GHK’s role in apoptosis - or cell death. Most cancer treatments work by causing cells to die. This prevents cell division, which also prevents tumor growth and spread. In vitro studies show that 24-hour treatment with GHK increases apoptosis by up to 3.3 times in neuroblastoma cells. It also negatively affects the viability and proliferation of malignant cells, which is good news for cancer patients.

Aside from playing a role in medical conditions, there are also other uses for this miracle compound. With animal studies, GHK-Cu has shown to have anti-pain, anti-anxiety, and anti-aggression properties. By administering specific doses through the skin, GHK-Cu can reduce anxiety and pain. These outcomes are speculated to be because of GHK’s ability to regulate genes. Of these genes, 7 of them are involved in pain modulation. (Pickart & Margolina, 2018).

In the future, these properties may be studied further by researchers and trial experiments. Once we have a deeper understanding of GHK-Cu, it may not be long before it is used as an active ingredient in different types of medications. 

Administration of GHK-Cu

As GHK-Cu can penetrate through the outer layers of the skin, topical application is ideal for facial and eye creams. Incorporating GHK-Cu in nano-sized liposomes may also further increase concentration levels in affected areas. 

Aside from cosmetic use, people that undergo dermatological procedures, such as laser treatment or chemical peels, can also use GHK-Cu to quicken wound healing.

With regards to safety, GHK-Cu is well-established in sunscreens, facial creams, serums and anti-wrinkle formulations. GHK-Cu has a wide variety of applications. It’s safe, effective, and most importantly, inexpensive.

GHK-Cu topical works wonders for those that are struggling with fine lines, wrinkles, or hyperpigmentation. It acts directly on fibroblasts to repair damaged tissue and keep it looking healthy.

Additionally, GHK-Cu restores lost proteins and components to help you return to your youthful self! Call us to get yours today!

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