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Aesthetics

Microneedling and Serums: Your Way to Smoother, Tighter, Greater Skin

microneedling-injection-and-infusion-clinic-abq

Let us face it: we could only wish for our skin to remain youthful even as we age.

Time causes collagen production all throughout our body to slow down, and as it does, our skin begins to sag and lose its glow. 

Aging, pregnancy, childbirth and even stress takes its toll on our skin and it overall affects the way we see ourselves. And truth be told - skin problems can be very distressing especially when it involves scars, stretch marks, and yes, wrinkles! 

With a lot of breakthroughs in the field of dermatology, it seems that every skin problem has already been addressed through a specific procedure or product. But this time let us talk about a breakthrough in dermatology: microneedling.

It is one of the most talked about skincare procedures of all time, with dermatologists leading the promotion of this specific technique. Also known as collagen induction therapy (CIT), microneedling is a successful and proven procedure which you can safely have at The Injection and Infusion Clinic of ABQ.

It is minimally invasive, highly effective, with little to no downtime, and produces visible effects in as early as one to two weeks after your first treatment. The process involves a series of 3-4 sessions four weeks apart. Since we keep aging, repeating a single session booster every six months is recommended.  The results are well worth it.  

Microneedling does not produce immediate overnight results. You will notice smoother feeling skin the very next day. It sure does provide lasting results!

microneedling injection and infusion clinic abq

Microneedling History: Bits and Pieces

The practice of microneedling dates to back to as early as 1905? 

Way back in 1905, a German dermatologist pioneered the use of a device with rotating wheels and rasps that was used to treat acne scars, keratoses and hyperpigmentation.1 It was relatively primitive compared to what we have today, but the concept remains.

In 1995, the concept of “subcision” was introduced by two doctors, David Oreintreich and Norman Oreintreich.

They initiated the concept of using tri-beveled hypodermic needles inserted through a puncture in the skin surface, with its sharp edges maneuvered carefully, thus inducing wound healing. The depression caused by the connective tissue is released, thereby giving a permanent solution to depressed scars and wrinkles.

Dr. Desmond Fernandes, by the year 2006, developed the first microneedling product based on the concept of percutaneous collagen induction, which is now known to us as the “dermaroller”. 

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Fast facts: What is microneedling and how does it work?

Professional microneedling involves using a roller product to make fine, uniform pinprick wounds on the epidermis to stimulate the production of growth factors, as well as collagen and elastin. The mechanism basically taps on the body’s natural healing mechanisms to improve one’s skin. 

Microneedling is usually done on the face to reduce scars, wrinkles, sagging, or large pores. It may also be done on other problem areas other than the face which have depressed scars. It is a cosmetic procedure that costs less than laser treatments with almost the same benefit. 

Because the body responds the same way to both large wounds and tiny wounds, the basic principle is that microneedling tricks the body to respond to these tiny wounds with the same rush of fibroblasts and growth factors towards the skin surface.

The most popular microneedling device, the dermaroller, involves the use of 0.5 to 2.5mm micro-fine needles on the skin. This is usually used at home treatments, however, it has a lot of disadvantages over modern microneedling pens, an innovation used by a lot of clinics today instead of the mechanical dermarollers.

The dermaroller is more agonizing and traumatic because the needles penetrate the skin at a 45° angle. This result in “tears” as the device is dragged on the skin, hence leading to more side effects and longer recovery time.

Microneedling pens are motorized and penetrate the skin vertically in a “stamping” motion, thus producing clean and precise puncture wounds. The skin experiences lesser trauma resulting in faster healing time.

Microneedling pens are also more versatile, which allows easy access to areas of the face such as the upper lip, around the nose, and around the eyes.

Furthermore, unlike dermarollers, microneedling pens are consistent, penetrating the skin up to 100 times per second with an adjustable speed. Ability to adjust the speed minimizes skin damage, a feature that can never be achieved using a manual dermaroller.

Here at The Injection and Infusion Clinic of ABQ, we use microneedling pens to ensure an efficient and sanitary procedure, with little to no downtime at all.

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Research and Studies

Various systematic reviews have established the safety and effectiveness of microneedling as a therapeutic option for the treatment of scars and wrinkles. In fact, it has become a part of the skin care practices of most dermatologists and aesthetic professionals.

Microneedling works through stimulating intradermal collagen production and was also used in achieving trans-epidermal drug delivery. Most clinics today suggest microneedling coupled with the use of serums on the skin’s epidermis, which can be directly delivered using the same procedure.

The Injection and Infusion Clinic of ABQ highly recommends applying a product called GHK-Cu for its additional collagen stimulating results.  We find this to be a superior to platelet rich plasma, which was made popular by the Vampire Facial™.  This method also does not involve any blood products and therefore removes any chance of cross-contamination.

Microneedling is also referred to traditionally as collagen induction therapy, designed to address facial scarring and to induce skin rejuvenation. 

In a 2017 study, results showed that combined treatment resulted in increased collagen production in the skin, and that combined treatment produced better results than each technique done alone.

This established the effectiveness of microneedling in effective collagen and elastin production. 

Another study in 2015 evaluated the use of multiple microneedling sessions in skin rejuvenation. Results showed that there was a significant increase in level of collagen type I, III, and VII, and more tropoelastin was noted from baseline after six microneedling sessions at two-week intervals.

Therefore, though microneedling may not produce immediate results, having multiple sessions can add to the improvement attained. It was noted that overall youthful appearance of the skin was achieved by reducing fine lines and wrinkles, reducing pore size, increasing suppleness, and increasing elasticity.

These results are even made better once coupled with serums such as hyaluronic acid and the above mentioned GHK-Cu application. 

Another study involving fractional microneedling radiofrequency in large multicenter trials noted that the procedure was highly effective in wrinkle reduction. In effect, microneedling is indeed an effective treatment modality, proving to be effective even on people with darker skin types of which risk of post-inflammatory pigmentation is very high.

Based on your skin requirement and needs, The Injection and Infusion Clinic of ABQ can also suggest the use of anti-aging serums that can assist you for you to have the best skin ever!

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The Microneedling Procedure

Microneedling is a simple office-based procedure that lasts for approximately 10 to 20 minutes, depending on the area to be treated. Total preparation and procedure time last approximately one hour.

Patients should be aware of the expected outcomes and the delayed response, and a thorough counselling is regularly done prior to the procedure. Most clinics recommend a total of four - six sessions spaced at 4 to 6 weeks apart depending on the problem at hand.

First, the face or the skin surface area of concern is cleansed using medical-grade facial cleanser. After drying, a topical anesthetic is then applied all over the area, and this is allowed to set in for about 20 minutes. 

Depending on clinic protocol and your treatment of choice, a serum promoting wound healing and skin repair is then applied. You can also choose to forego this step. 

Then it is time to start needling! The process of microneedling is initiated using a microneedling pen - device that basically induces a “controlled injury”. Needling is done by running the device with fine needles across the skin surface area of concern vertically, horizontally, and diagonally.

Through our specialized microneedling pen, fine needles basically go up and down the skin very rapidly as it is glided across your skin creating hundreds of micro-holes per section.  Skin thickness varies even in the face so make sure you do the process with a licensed and microneedle certified provider who knows how to adjust the depth of the needles and manipulate the extent of penetration based on the area involved. 

Once the needling process is done, the clinician proceeds to applying a soothing layer of serum. The numbed sensation lasts for several hours and there is little to no discomfort post-procedure.  Exercise can make you feel like the skin is burning, so we recommend 24 hours of no exercise or at least no aerobic exercise at all.

Protection is vital. Sunscreen application is a must! Most clinics slather on their patients a generous amount of sunscreen prior to discharge.  And since we do not want any chemicals on the face, we use barrier sunscreen like zinc oxide which has a whiteish appearance.

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Side Effects and Risks Involved

Just like any area of the skin that has experienced injury, a couple of side effects can be readily noted:

  • Pinpoint bleeding

Do not be surprised to see areas of pinpoint bleeding after the procedure. Be assured that these are minimal and painless. 

  • Pain and redness

You will experience redness and possibly a slight burning sensation for about 24 hours.  During these 24 hours, your pores are open.  This is the best time to slather hydrating creams and collagen stimulating products, like GHK-Cu.  And again, do not forget to apply sunscreen!

  • Mild itchiness

Since the process induces micro-injuries, you can expect mild itchiness accompanied with tightening of the skin up to a few days post-procedure.

  • Melasma and keloid formation 

If you are prone to keloid formation, it is critical that your clinician knows this.  There are ongoing studies suggesting that microneedling can be a good alternative treatment to help reduce the appearance of inactive keloids and melasma. The key is a gentle approach. The process for keloids and melasma requires more sessions and may take up to eight months for maximum results.

  • Infection

Due to the microinjuries sustained by the skin, the skin also becomes prone to infection. This happens if the instrument used has not been properly disinfected or sterilized. Make sure you do the procedure at a trusted clinic to limit the chances of getting an infection. The Injection and Infusion Clinic of ABQ uses a NEW, sterile head for every procedure!  Also, these microinjuries enhance the delivery of any toxic products to your system, so ask the clinic regarding any skin care regimen.  You should make sure you are using non-toxic products on your extremely sensitive skin at this point.

No reason to worry though, microneedling is very safe and well-tolerated by all skin types!

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Aftercare

Chemical-free sunscreen with at least SPF 30 is recommended during the weeks following treatment.

Products containing retinol and acids such as glycolic acid and salicylic acid are also discouraged, as the skin may not be able to tolerate strong ingredients right after the procedure. Go for mild skin products and avoid exfoliating scrubs temporarily.

Hydration is still a must! Aside from drinking lots of fluids, make sure to put on hydrating serums and creams. 

If you need to put on makeup, go for light and hypoallergenic makeup. Make sure to remove it prior to bedtime.

On DIY Derma-Rolling VS Microneedling in Clinics

A lot of do-it-yourself derma-pens and derma-rollers have come out in the market today, and though visible effects can be noted early on after the procedure, most of these offer short-lived and temporary results. This is most often because these products have shorter needles hence lesser skin penetration.

Do-it-yourself microneedling may be cheaper than that done in clinics, but it comes with a lot of risks especially in terms of infection control.

Having your microneedling procedure at a trusted clinic like The Injection and Infusion Clinic of ABQ guarantees you that the procedure is handled by an experienced professional. On top of that, you have ready access to serums and other topical products that will improve your overall microneedling experience!

Book an appointment with us TODAY!

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Aesthetics

The Fountain of Youth: Anti-aging Senescent Cells

food sensitivity test injection and infusion clinic abq 7

The Inevitable Process of Aging and its Consequences

Aging is a process everyone goes through. As we age, our bodies gradually lose their bioprotective and regenerative mechanisms and become vulnerable to various diseases. (Flint & Tadi, 2020). 

If you look older than your age, don’t be concerned!  The condition of your body shows the real fountain of youth, not your appearance. There are two types of aging: successful vs. pathological.

Successful aging refers to the state of being disease-free as an elderly adult. The following traits characterize it:

  • Able to function at optimal levels both physically and mentally
  • Do not require medications for health issues like diabetes or hypertension
  • Minds are sharp and can hold a decent conversation
  • Rarely visit the hospital
  • Looking younger than their age

Comparatively, pathological aging may bring about changes that can make our body prone to develop specific diseases: 

  • Neurological: Higher neurodegeneration, accumulation of abnormal proteins can lead to Alzheimer’s disease, Parkinson’s disease, cerebral atrophy, or shrinking of the brain
     
  • Renal/Kidneys: Lower number of glomeruli/filtering units of the kidneys may lead to acute or chronic kidney disease

  • Gastrointestinal: Loss of taste and smell, slower digestion, and changes in gut bacteria composition can lead to appetite problems and nutrient deficiencies. Constipation and bowel obstructions can become more common as we age. The metabolic activity of the liver also decreases.

  • Cardiovascular: Slowly, the cardioprotective mechanisms in place when we were younger become less efficient. As the blood vessel walls stiffen, the heart muscle walls thicken. The valves become calcified and become more prone to develop coronary heart disease and heart failure.

  • Respiratory: Our chest wall becomes less compliant and elastic, which eventually makes it more difficult to breathe. The capacity of our lungs may also decrease. A simple viral infection can lead to pneumonia, respiratory distress, and eventually, respiratory failure.

  • Endocrine: Hormones that exert specific protective effects like testosterone, estrogen, and progesterone decline as age. Menopausal women become more prone to develop fractures and cardiovascular diseases as a consequence of this decline. Production of thyroid hormones and insulin may also decrease. Dysregulated insulin production can lead to diabetes.

Available interventions in the market treat each of these diseases separately. For example, take a 65-year-old woman with diabetes and hypertension. She would require two maintenance medications - Metformin, an antidiabetic drug, and Losartan, an antihypertensive drug.

As this woman ages, she may eventually develop complications like kidney damage or a heart attack - this would require the addition of two more medications. 

Requiring multiple medications to manage many illnesses is known as polypharmacy - the need for multiple drug prescriptions. In elderly individuals with numerous diseases, it becomes a common phenomenon.

Instead of looking at diseases separately, we should understand why our bodies develop them in the first place. As we already know, aging declines our bodies’ protective mechanisms and makes us vulnerable to diseases.

Thus, if we can target the cellular mechanisms that lead to these diseases, we can prevent them and the need for multiple drug prescriptions.

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What Happens to Our Bodies’ as We Age?

There are three main cellular processes involved in aging. These are the accumulation of metabolic waste, reduced replicative capacity, and damage accumulation through excess free radicals. 

Accumulation of Metabolic Waste

One by-product of metabolic waste involves glucose. Glucose reacts with other molecules like proteins in our body to form glycosylated end-products. 

As we age, our blood glucose control becomes dysregulated, leading to increased blood glucose levels. The increased glucose present in the bloodstream produces more glycosylated by-products. On a microscopic level, this contributes to the thickening of tissue membranes, fibrosis of vascular walls, and reduced collagen elasticity.

Reduced Replicative Capacity

Reduced replicative capacity, or senescence, refers to the inability of our cells to divide and replicate. As a result, apoptosis, or cell death occurs. Apoptosis is a natural phenomenon in our bodies and programs damaged or injured cells to die. In turn, our cells also have an innate replicative capacity and allow them to replace lost cells.

As we age, the proteins that control the replicative function of our cells declines. As a result, the signals that drive the replication process decline as well. In contrast, the factors that promote cell death or apoptosis continue to function, leading to an overall decrease in healthy and functional cells in our body.

Excess Free Radicals

In biochemistry, free radicals cause adverse health impacts and are unstable molecules that readily react with the molecules around them. 

Our bodies naturally produce free radicals in small and controllable amounts every single day. Simultaneously, we also have built-in antioxidant mechanisms that control their numbers and keep them from getting out of hand. As we age, these antioxidant mechanisms decrease in activity, leading to an increase in free radicals.

Free radicals, in excess amounts,  can damage proteins, cell membranes, nucleic acids, and organelles inside our cells. As more organelles become affected, the cell itself becomes damaged. Over long periods , free radicals eventually lead to cell death.

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What are Senescent Cells?

The three main processes involved in aging are linked to one another and contribute to aging’s overall pathophysiology.  All of these processes eventually lead to cellular senescence or senescent cells.

Senescent cells are damaged cells that can no longer replicate. Strange enough, the inability to divide is a protective mechanism. If damaged cells continued to replicate, it would lead to the creation of more damaged cells, which would eventually lead to cancer. As a result, senescent cells are considered defective cells. 

At a young age, the body’s ratio of healthy cells to senescent cells is negligible. However, as we get older,  our bodies’ cells undergo more damage, lose their ability to divide, and become senescent cells. 

Some studies have also found evidence senescent cells are resistant to apoptosis or cell death. When enough of these damaged cells accumulate, they manifest as specific diseases.

One of these diseases includes osteoarthritis, a painful condition of the joints associated with wear and tear from aging. The accumulation of senescent cells in the space between our joints causes osteoarthritis.

 Also, senescent cells secrete SASPs - senescence-associated secretory phenotypes. SASPs include harmful molecules like proinflammatory cytokines and proteases and contribute to tissue dysfunction and chronic inflammation.

We mentioned earlier that instead of treating the many diseases associated with aging individuals, a better method is to prevent them from arising. Targeting senescent cells might treat and prevent age-related diseases and promote successful aging.

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What are Senolytic Agents?

Products that target the removal of senescent cells have been the subject of many studies in the past years. These are called “senolytic” agents, a peptide, an antibody, or a compound that acts specifically on senescent cells or its harmful secretory peptides. (Kirkland et al., 2017). 

One study explored the effect of a senolytic combination of dasatinib and quercetin in senescent cells. Dasatinib is a drug used to treat leukemia, while quercetin is a plant flavonoid with antioxidant properties. 

This study used a sample of human fat. Researchers observed the senolytic cocktail not only eliminated the senescent cells but also decreased its production and secretion of harmful proinflammatory cytokines.

There was a marked improvement in physical function and reduced mortality risk by 65% when the cocktail was administered to aged mice.

More potential senolytic compounds were explored and studied in the past decade; most are flavonoids or plant-derived senolytic products. Flavonoids are phytonutrients found in most fruits and vegetables.

Aside from giving plants their color, flavonoids also have antioxidant and anti-inflammatory properties. Additionally, they are also responsible for the health benefits of the intake of fruits and vegetables.

Natural Senolytic P


Fisetin

Fisetin is a plant flavonoid found in wax trees, strawberries, persimmons, cucumbers, and onions.

Studies have shown fisetin has antioxidant, anti-inflammatory, antiangiogenic, and neuroprotective effects. Fisetin, as a flavonoid, can “clean up” the free radicals responsible for cellular and organelle damage. 

One study showed fisetin increases the death of cancerous cells without significantly affecting healthy cells. Fisetin selectively induces apoptosis (cell death) for senescent cells. Fisetin, compared to other flavonoids,  has the most potent senolytic activity.

Quercetin

Quercetin is a flavonoid found in tea, red wine, and certain vegetables. Medical remedies like St. John's wort, Ginkgo biloba, and American elder are also sources of Quercetin.

Quercetin has a wide range of health benefits. It exhibits antioxidant, anti-inflammatory, anti-obesity, antiviral, and antibacterial properties. Nowadays, quercetin can be found as a central component in certain nutritional supplements.

When it comes to senolytic activity, quercetin exerts its anti-aging properties by acting as a powerful antioxidant. Studies have shown it can effectively remove senescent cells in this way. Quercetin, combined with an anti-cancer drug like dasatinib, increases its senolytic activity.

Resveratrol

This plant-derived polyphenol may sound familiar to you. Resveratrol has been studied extensively in past decades for its role as an anti-aging molecule. Resveratrol is famously known as a component of red wine but, various peanuts and berries also contain resveratrol.

Resveratrol acts on the proteins AMPK and Sirt1 as a potent anti-oxidant and anti-inflammatory agent. It cleans up free radicals, reduces oxidative stress, and even increases a cell's antioxidants. Resveratrol's anti-inflammatory properties can reduce harmful pro-inflammatory cytokine levels and improve the function of mononuclear cells.

Mononuclear cells are your body's natural defenders. Antioxidants and anti-inflammatories lessen skin aging and provide neuroprotection and relief for osteoarthritis.

In recent studies, resveratrol protects against arterial aging. Resveratrol reduces the thickness and stiffening of major blood vessels to the heart, known to contribute to cardiovascular diseases.

Growing old is an inevitable process all of us will have to one day face. The steps you take and the nutrients you feed your body today will determine whether you age like fine wine or expire like sour milk.

The complications associated with aging are due to senescent cells that accumulate in the body. Thus, by reducing or eliminating the number of senescent cells, you can remain in optimal health and become less vulnerable to diseases and illnesses.

The Injection and Infusion Clinic of ABQ offers senolytic - a dietary supplement that can reduce senescent cells in the body. Senolytic also contains pterostilbene and curcumin, which are powerful anti-aging ingredients. If you want to learn more about how you can age gracefully, get in touch with us today!

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what is ghk-cu
Aesthetics, Peptides

What is the GHK-Cu Peptide? Benefits and Applications

what is ghk-cu

What is GHK-Cu?

Everyone wants to look young, but few know about the compound GHK-Cu. It’s regarded as high-interest in the scientific community, due to its regenerative properties. And as you’ll soon find out, GHK-Cu may just be the key ingredient to everlasting youth.

GHK stands for the amino acids glycyl-L-histidyl-L-lysine. It’s a small, naturally-occurring peptide that binds to copper. In the presence of injury, our body produces this compound to accelerate healing and regeneration.

GHK-Cu is present in collagen, the main structural protein of connective tissues in the body. One early study described its role in skin repair. Researchers discovered that GHK promotes the production of cells that make up the extracellular matrix.


These cells consist of collagen, as well as glycosaminoglycans and decorin. Glycosaminoglycans prevent the accumulation of damaged proteins and excessive protein breakdown in the site of tissue injuries.

Besides being a miracle that can reverse aging, it is also known as a gene regulator. On a molecular level, it interacts with specific types of genes and can either activate or deactivate them. As a result, it’s no surprise that it has been studied extensively across laboratories worldwide.

As of today, GHK-Cu has been associated with the following properties:

  • Makes skin more smooth, firm, and clear
  • Decreases depth of wrinkles and reduces fine lines
  • Decreases skin spots and hyperpigmentations
  • Promotes wound healing
  • Protects the skin from the sun
  • Anti-inflammatory
  • Promotes hair growth

Peptides for Skin and Hair

One peptide combo even has a botox-like effect! While there are many products available, the Injection & Infusion Clinic of ABQ has focused on the most effective!

If GHK-Cu is something our body naturally produces then why do we still develop wrinkles and fine lines? Why do we still have skin spots and why do we still need sunscreen for UV protection?

The answer to this question is the same problem scientists have spent years trying to solve: age. Children and young adults have especially high GHK-Cu levels. However, as we get older, our GHK-Cu levels decrease.

To put things into perspective, someone at 20 years of age would have approximately 200ng/mL of GHK-Cu. At 60 years of age, this amount goes down to 80ng/mL. As a result, our skin loses its firmness and elasticity as we mature.

medical applications

Cosmetic Application of GHK-Cu

Fibroblasts are cells that produce the extracellular matrix, which make up the main component of connective tissues. The ability of GHK-Cu to modulate collagen synthesis in fibroblasts makes it an ideal component for many skin and hair products.

Even without copper, GHK can increase the number of keratinocytes, which are cells found in the outermost layer of our skin. Additionally, GHK can also
increase the expression of integrin - a protein that strengthens cell adhesion.

In one study, a group of women used a facial cream with GHK-Cu for 12 weeks. After the 12 week timeframe, the participants had firmer skin with less fine lines. The depth of their wrinkles decreased, and the overall clarity of their skin improved.

Besides being used in facial creams, it is also effective as eye cream. In another study, 41 women used a GHK-Cu eye cream for 12 weeks.

Compared to the group that used a placebo containing Vitamin K, the participants that used GHK-Cu eye cream around their eyes had less wrinkles and fine lines. The density and thickness of their skin also improved.

Products that contain GHK-Cu can also improve skin hydration and skin elasticity. Some studies made use of GHK-Cu encapsulated in nano-lipid carriers. Women that applied these products throughout the span of 8 weeks had 31.6% reduction in wrinkle volume, compared to groups that used a different product.

In hair products, GHK-Cu can improve hair follicle size. It is also known to improve hair transplant success because of its role in fibroblast and keratinocyte proliferation.

Peptides for Skin and Hair

GHK-Cu stimulates collagen and increases skin thickness, which decreases fine lines and supports sagging skin. Contact us at 505-445-4300 to order!

ghk cu the injection and infusion clinic of abq

GHK-Cu can Improve
Wound Healing

Your body has a natural way of healing itself over time. However, this healing process does not occur unless there is an inflammatory response, such as a tissue injury. As a result, the skin or tissue that results afterwards may appear different, as in the case with scars.


GHK-Cu helps our body to heal faster, by attracting macrophages and mast cells to repair the area of injury. This reduces the amount of free radicals produced in the inflammatory process, which can improve the formation of granular tissue.


GHK-Cu also increases the production of factors that promote blood and nerve vessel growth. Large volumes of blood are an essential component in speeding up the healing process. This is because blood provides the nutrients and oxygen needed by our cells.


As GHK is a gene regulator, it can also inhibit blood vessel growth in the latter parts of the healing process. Without this inhibition, healed skin tissue would be more sensitive to stimuli than usual. This is also why adequately healed skin tissue often lacks sensation. As well, studies have shown that GHK can also promote the growth of nerve cells.

Multiple studies on animals have demonstrated the wound healing properties of GHK-Cu. In scald wounds of mice, administration of GHK-Cu liposomes resulted in better angiogenesis - or blood vessel growth. After application of GHK-Cu, these scalp wounds healed after a minimum of 14 days with minimal scarring.

In thick open wounds of rabbits, application of GHK-Cu resulted in faster reduction of wound size compared to application of zinc oxide and no treatment groups. Researchers noted that neovascularization - or blood vessel growth, performed better for the rabbits in the GHK-Cu group. They correlate this outcome to shorter healing time.

injection-&-infusion-clinic-of-abq-ghk-cu-medical-applications

Other Medical Applications

*Unfortunately in 2020, the FDA severely restricted/eliminated the ability to obtain GHK-Cu injectable. Therefore, non-topical applications are not currently accessible.

1

Acute Lung Injury

Acute lung injury - or ALI, is characterized by severe inflammation that results in tissue injury. If it progresses, ALI can become acute respiratory distress syndrome, which is characterized by hypoxemia, lung edema and difficulty breathing.

Before the COVID-19 pandemic, the incidence of ALI was 1.5 to 100 per 100,000 person-years (Park et al, 2016). Presently, the prevalence of acute lung injury in severe COVID-19 infectees is 30%. Studies have shown the occurrence of ALI can predict the prognosis of a patient (Li et al., 2020).

The role of GHK-Cu in acute lung injury has only been studied on animals; however, the results are promising. ALI is caused by excessive neutrophil infiltration in the lungs, and GHK-Cu has been found to counteract this harmful effect. In a similar study performed on mice, researchers discovered that GHK-Cu can reduce TNF-α and IL-6 expression, which are both involved with an inflammatory reaction in the lungs (Park et al, 2016).

These early studies give researchers hope. The discovery of these outcomes provides the groundwork for future treatments involving acute lung injury, and acute respiratory distress syndrome.

2

Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease - or COPD, is a chronic lung disease characterized by bronchitis or airway inflammation, emphysema and asthma. It is a lifelong illness that requires maintenance medications to decrease the frequency of attacks. 

GHK-Cu is a gene regulator that influences the expression of several genes in the human genome. Recent literature has discovered that GHK-Cu can affect the expression of 127 genes in COPD patients. Excessive expression of certain genes can also increase inflammation in COPD, while decreasing the expression of genes that are responsible for repair. GHK-Cu was postulated to reverse this gene expression pattern found in COPD patients, by activating a different pathway. 

Researchers have also performed in vitro experiments with positive results. GHK was added to the lung fibroblasts of COPD patients with impaired repair mechanisms. After treatment with GHK, this function was restored (Pickart & Margolina, 2018).

2

Cardiovascular Diseases

Fibrinogen is a protein manufactured by the liver. In the presence of tissue injury, it forms a clot to stop bleeding. However, too much fibrinogen can also be a bad thing, as it makes blood more viscous and prone to clotting. This results in an increased risk of cardiovascular complications like heart attacks and strokes. 

GHK has also been shown to suppress IL-6, a protein regulator needed for the production of fibrinogen. This experiment was observed in vitro and in vivo in mice. Overall, outcomes conclude that GHK can suppress the production of too much fibrinogen. (Pickart & Margolina, 2018).

2

Cancer

Any compound that increases cell growth also has the potential to become cancerous - except GHK-Cu. In 2010, researchers explored the anti-cancer properties of over 1000 bioactive molecules. Only 2 substances were able to suppress the metastatic genes; one of these was GHK.

On top of not having cancer-related symptoms, GHK can downregulate RNA synthesis in patients with cancer. 70% of genes that are overexpressed have been shown to return to normal after treatment. Based on these outcomes, it appears that GHK isn’t just randomly suppressing and upregulating genes. In fact, it may actually reset the activity of these specific genes, allowing them to act the way they’re supposed to.

More specific studies explored GHK’s role in apoptosis - or cell death. Most cancer treatments work by causing cells to die. This prevents cell division, which also prevents tumor growth and spread. In vitro studies show that 24-hour treatment with GHK increases apoptosis by up to 3.3 times in neuroblastoma cells. It also negatively affects the viability and proliferation of malignant cells, which is good news for cancer patients.

Aside from playing a role in medical conditions, there are also other uses for this miracle compound. With animal studies, GHK-Cu has shown to have anti-pain, anti-anxiety, and anti-aggression properties. By administering specific doses through the skin, GHK-Cu can reduce anxiety and pain. These outcomes are speculated to be because of GHK’s ability to regulate genes. Of these genes, 7 of them are involved in pain modulation. (Pickart & Margolina, 2018).

In the future, these properties may be studied further by researchers and trial experiments. Once we have a deeper understanding of GHK-Cu, it may not be long before it is used as an active ingredient in different types of medications. 

Administration of GHK-Cu

As GHK-Cu can penetrate through the outer layers of the skin, topical application is ideal for facial and eye creams. Incorporating GHK-Cu in nano-sized liposomes may also further increase concentration levels in affected areas. 

Aside from cosmetic use, people that undergo dermatological procedures, such as laser treatment or chemical peels, can also use GHK-Cu to quicken wound healing.

With regards to safety, GHK-Cu is well-established in sunscreens, facial creams, serums and anti-wrinkle formulations. GHK-Cu has a wide variety of applications. It’s safe, effective, and most importantly, inexpensive.

GHK-Cu topical works wonders for those that are struggling with fine lines, wrinkles, or hyperpigmentation. It acts directly on fibroblasts to repair damaged tissue and keep it looking healthy.

Additionally, GHK-Cu restores lost proteins and components to help you return to your youthful self! Call us to get yours today!

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3-Impressive-Anti-Aging-Therapies-You-Need-to-Know-Right-Now-Injection-Infusion-Clinic-of-ABQ
Aesthetics

3 Impressive Anti-Aging Therapies You Need to Know Right Now

 3-Impressive-Anti-Aging-Therapies-You-Need-to-Know-Right-Now-Injection-Infusion-Clinic-of-ABQ

Worried about premature skin aging?

Coco Chanel once said, “Nature gives you the face you have at twenty; 
it is up to you to merit the face you have at fifty.”

Let’s face it. For thousands of years, men and women have pursued the fountain of youth. Anti-aging therapies have come a long way!

In this article, we will explore our top 3 impressive anti-aging therapies that every woman needs to know about along with each other their own:

  • Benefits
  • Efficacy & Safety
  • Side Effects
  • Procedure
  • and more!

The Anti-Aging Evolution

You’re not the only one who’s interested in maintaining your youthful glow. Let’s track down famous people with their anti-aging rituals and quests.

  • Cleopatra, Egyptian queen: She bathed in sour donkey’s milk squeezed from 7,000 donkeys. She probably got it right since milk contains alpha-hydroxy or lactic acid. This peels-off skin, leaving it smooth and blemish-free. She also used crocodile dung to enhance her complexion. Ew!

  • Galen, the Greek physician: He invented the cold cream. It forms an emulsion of beeswax, water, olive oil, and scents. It smooths the skin and removes impurities.

  • Juan Ponce de León, Spanish conquistador: He journeyed far and wide in search of the eternal fountain of youth, literally. His efforts weren’t entirely futile since he stumbled upon Florida...although not exactly anti-aging.

  • Elizabeth I, Queen of England: Her royal highness used Venetian ceruse as a skin-whitener. It’s composed of white lead and vinegar. Unfortunately, lead causes  greying skin and wrinkles. To help hide these adverse effects, Elizabethan women glazed their faces with raw eggs.

  • Margaret Kroesen: Sometime in 1889, her daughter’s frown lines inspired her to develop a wrinkle smoothing-patch. Frownies, as it was called, helped smooth the skin.

The Anti-Aging Revolution

By the 20th century, the beauty and cosmetics industry started manufacturing a wide array of anti-aging products. These are cosmetic hormone creams, albumin wrinkle smoother, retinol or Retin-A, Botox, vitamin C serum, hydraulic acid, moisturizers, and sunscreens.


You apply these products on your skin. Although these products do help, skin aging goes deeper than the outer layer of skin. Some skin wrinkles, scars, or stretch marks need more than the regular application of anti-aging products for long-term effects.

MICRONEEDLING-3-Impressive-Anti-Aging-Therapies-You-Need-to-Know-Right-Now-Injection-Infusion-Clinic-of-ABQ

Microneedling

step 1

Microneedling and its Benefits

Microneedling, also called dermarolling, was first described in 1995 as percutaneous collagen induction. A trained healthcare provider uses a microneedle device in this minimally invasive procedure.

Fine needles run over your skin creating pinpricks. The pinholes stimulate wound healing and the production of collagen and elastin. This minimizes acne scars, fine lines, and photo-aging.

It’s perfect for scar revision, skin revitalization, texture improvement, stretch marks, body scars, and thinning hair. The pinholes on the skin also become a way for introducing skin-care products...like the peptide GHK-Cu.

2

Microneedling is Effective and Safe

Yes, microneedling is an effective and safe therapeutic option for various skin conditions . This was concluded by researchers who conducted a comprehensive review of microneedling.

They looked into PubMed, Medline, and ScienceDirect studies to support this claim. These studies included people as study subjects who have undergone random trials.

Based on their review, microneedling resolved skin problems such as acne, excessive sweating (hyperhidrosis), hair loss (alopecia), scars, gray or brown patches (melasma), and overexposure to UV light (photodamage).

Book a FREE Microneedling Consult!

Perfect for Fine Lines, Acne Scars, Photo-Aging, Scar Revision, Skin Revitalization, Texture Improvement, Stretch Marks / Body Scars, and Thinning Hair! For inquiries, call 505-445-4300 or book a FREE consult here!

3

Microneedling: Side Effects

You may experience minor discomfort as the microneedle works on your skin. Before the therapy though, a mild topical anesthetic is applied over your skin.

Since your skin has pinholes, you may unintentionally apply products that contain toxic substances. These substances get into the pinholes of your skin. It then causes harmful reactions once absorbed by your body.

So, you have to make sure the products you’re using are approved by your healthcare provider. Patients experience mild redness for about 24hours, which is much more manageable than the downtime experience with laser frequency and laser ablation.

4

Microneedling: The Procedure

Results are noted after one session, but maximum improvement occurs with four sessions, which are spaced four to six weeks apart. This downtime allows for skin repair and growth.

According to the study result of Ablon, microneedling therapy showed an improvement in lines, wrinkles, skin laxity, and texture after 90-150 days from the first session.

5

Microneedling: Effective means for peptide delivery

Peptides such as GHK-Cu stimulate collagen production and are beneficial for the appearance and health of the skin. Microneedling enhances skin penetration and offers an effective means to deliver peptides under the surface of the skin.

GHK-Cu-for-Aging-3-Impressive-Anti-Aging-Therapies-You-Need-to-Know-Right-Now-Injection-Infusion-Clinic-of-ABQ

GHK-Cu (copper peptide)

Discovered in 1973, GHK-Cu or glycyl-L-histidyl-L-lysine is a naturally occurring copper tripeptide. It can be found in your plasma, saliva, and urine. It aids in metabolism, promotes wound healing, and prevents liver damage.

GHK-Cu benefits your skin in many ways. Its antiaging property reduces your fine lines and deep wrinkles. It also smoothens, tightens, and clears your skin. Its other positive effects include reducing skin spots or blemishes as it protects you from harmful UV radiation. GHK-Cu is not only good for your skin but your hair, too. It promotes the growth and thickness of your hair.

GHK-Cu is effective and safe

  • Yes, GHK-Cu is safe as it repairs, regenerates, and protects the skin (Pickart and Margolina, 2018). This is based on a study they conducted to determine the regenerative and protective action of GHK-Cu on the skin. 
  • Its effects are anti-inflammatory and antioxidant. It serves as a response signal or protects your tissue after you suffer a skin injury. Its anti-inflammatory effect controls oxidative stress which can further damage your tissues that contributes to aging.
  • GHK-Cu is most abundant during childhood and declines with age. As you grow older, there is thus increased risk for tissue destruction, inflammation, and even cancer.
  • GHK-Cu has also been widely used in cosmetics with its anti-aging and reparative effects. Studies have been conducted to confirm its efficacy:

    • GHK-Cu topical cream did better than retinoic acid and vitamin C in boosting the collagen of 20 women who had photodamaged skin. 
    • GHK-Cu facial cream improved the skin appearance, clarity, and tautness of 71 women who participated in a 12-week study. Compared with placebo cream, the researchers noted that GHK-Cu increased skin thickness and density. It also lessened the depth of wrinkles and fine lines. 
    • GHK-Cu eye cream did better than vitamin K in reducing wrinkles and lines, increased thickness and density of the skin, and improved its appearance.
    • GHK-Cu cream stimulated the reproduction of the cells of the outer layer of the skin. Based on the same study, it also improved the skin’s density, appearance, and thickness.

No adverse effects

  • GHK-Cu was found to be non-irritating and non-toxic in at least three separate experiments. It has no adverse effects and can be incorporated in creams, dermal patches, foams, liposomes, microneedles, or subcutaneous injections.

Procedure

Two other cosmeceutical peptides

  • Argireline® peptide: Argireline (Arg) is a brand name of acetyl hexapeptide-3 or acetyl hexapeptide-8. Arg, a neurotransmitter, reduces the movement of your muscles to prevent the formation of wrinkles.

    It reduces your expression or fine lines, stimulates the production of collagen, and promotes moisture of your skin. It’s like botulinum toxin (Botox) with its wrinkle-smoothing effect.

    A study mentioned that Arg is safer than Botox with an efficacy rate of 48% with twice a day usage for four weeks. The researchers’ study revealed Arg3 was most effective among other Arg peptides they tested (Lim et al., 2018). There’re still no known side effects of Arg. Thus, it is safe for you.
  • Leuphasyl® peptide: Leuphasyl is a brand name of pentapeptide-3. It modulates the release of acetylcholine, a neurotransmitter, which reduces the contraction of muscles.

    This peptide goes hand-in-hand with Arg and other peptides. Its benefits are like Arg, with focus on your forehead and around your eyes.

    It’s less effective than Botox, but it has no side effects (Dragomirescu et al., 2014). Thus, it is also safe for you.
Glutathione-3-Impressive-Anti-Aging-Therapies-You-Need-to-Know-Right-Now-Injection-Infusion-Clinic-of-ABQ

Glutathione (GSH)

Glutathione & Its Benefits

GSH, dubbed the “master antioxidant”, is a tripeptide of cysteine, glycine, and glutamic acid. It’s a naturally occurring substance produced in the liver. It’s also found in meats, vegetables, and fruits.

It has been known to allegedly treat some diseases. To name a few, these are cataracts, cancer, diabetes, Alzheimer’s, and osteoarthritis. In general, GSH promotes longevity, protects the body from toxins, and maintains health (Pizzorno, 2014).

Glutathione Is effective for anti-aging

GSH is widely used for skin-lightening as it lessens age spots and dark marks. And, it lessens the pigmentation (melanin) in your skin.

Research suggests  you take it with vitamin C of equal or twice the dosage for best results (Priyadarshini, 2015). We find that glutathione improves the skin’s glow.  As an antioxidant, GSH cleanses the liver and kidneys of toxins for a healthier and refreshed-looking skin. 

GSH has also been shown to improve skin elasticity and helps reduce wrinkles or fine lines (Weschawalit et al., 2017). Collagen synthesis is likewise enhanced by GSH (Shan et al., 1994).

It works by regulating the transforming growth factor (TGF), which stimulates the production of collagen (Liu et al., 2004). 

Procedure

GSH can be taken in three routes; by mouth, nasal spray, or IV. For optimal results, GSH IV infusion is recommended.

Glutathione: Side Effects

GSH intravenous (IV) has no known significant side effects. GSH IV was observed to have no potential adverse reactions and its short half-life indicated limited duration of its effectiveness. (Fukagawa et al., 1996).

It was observed to be safe and tolerated by people with Parkinson’s disease in a study conducted at the University of South Florida (Hauser et al., 2009).

The study by Hauser was validated by a related study as a person did not notice any adverse effects during GSH IV infusion (Otto et al., 2018)

A review of related literature pointed out that GSH had no or minimal adverse effects, but further studies were suggested to assess its safety (Davids et al., 2017).

Ready to get the drip?

Microneedling, GHK-Cu, and Glutathione are only some of anti-aging therapies available in our clinic. For inquiries, call 505-445-4300 or email us at info@infusionclinicabq.com today!

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