Polycystic Ovary Syndrome or PCOS is one of the common causes of infertility among women of child-bearing age. It affects 6-12% or an estimated 5 million women in the US (CDC, 2020). Women with PCOS are at risk of developing Type-2 diabetes, endometrial cancer, heart problems, and high blood pressure (John Hopkins Medicine, n.d.).
If you’re one of these women, there’s a promising therapy for you. This therapy is Lipostat/MIC. It consists of Methionine, Inositol, and Choline. It’s a fat burner injection that also works to increase fertility.
A study supported the beneficial effect of Inositolfor women with PCOS (Gerli et al., 2003). In 2003, Scientists conducted a placebo-controlled study among 283 women with PCOS. An Inositol dose of 100 mg was given to the 136 women twice a day. The 147 women received a placebo. The results showed within a week of the study, the Inositolgroup lost weight and had rapid maturation of follicles. The placebo group, though, gained weight.
Benefits of Inositol for Women with PCOS
Lipostat contains Inositol. Other than helping women with PCOS lose weight, Inositol plays a significant role in fertility. It comes in various forms such as myo-, cis-, and d-chiro. These forms are also called metabolites which regulate your menstrual cycles and improve your ovarian function, among others. Scientific studies back the benefits of Inositol.
- Inositol had positive effects on the modulation of female metabolic and reproductive pathways (Genazzi, 2016). As a natural compound, it can be a treatment option for PCOS.
- Inositol has also been proven effective in PCOS by improving hormones and restoring ovulation in women (Lagana et al., 2018).
- Both myo-Inositol and d-chiro-Inositol are potential therapies for women with PCOS (Formuso et al., 2015).
- The crucial point was the proper ratio of myo-Inositol and d-chiro-Inositol in treating women with PCOS (Nestler and Unfer, 2015). Another study also found the combination of myo-Inositol and d-chiro-Inositol was effective in treating PCOS. The ratio of 40:1 restored the function of the ovaries and metabolic balance (Monastra et al., 2016).
- Inositol in PCOS improved the ovarian function of women trying to conceive through assisted reproductive technology (Garg and Tal, 2016).
For more details on its efficacy, let’s learn more about PCOS first. The direct cause of PCOS is unclear and not fully known yet. But excess androgen and family history are associated with it. Moreover, PCOS links to low-grade inflammation (Gonzales, 2013), obesity (Sam, 2007), and insulin resistance (Højlund, 2014). Researchers claimed PCOS might originate with various mineral or vitamin deficiencies (Güinalan et al., 2018).
Symptoms of PCOS
Symptoms may not be obvious. And some women find out they have PCOS only when they have trouble getting pregnant. The symptoms may include the following:
- Irregular, very light, or no periods due to the absence of ovulation
- Excess hair on the body and face while thinning scalp hair due to higher than normal levels of male hormones or androgen
- Larger than normal ovaries due to multiple cysts
- Bulging belly or weight gain
- Oily skin or acne
- Thick or dark skin patches under the breast, armpits, and the back and neck (John Hopkins Medicine, n.d.)
3 Therapies for PCOS
Your primary healthcare provider may prescribe birth control pills to regulate your menstrual cycle. These pills contain progestin and estrogen that decrease androgen or male hormones. Taking these pills lowers your risk of endometrial cancer and minimizes acne and excessive hair growth.
You may also be prescribed with medications that make you ovulate or release eggs. Some of these are Clomiphene, Femara, Metformin, and injectable Gonadotropins. Fertility medications may cause side effects such as abdominal bloating and pelvic discomfort. There’s a risk of multiple births, too.
- Healthy diet and lifestyle:
Some women with PCOS are overweight. You can verify this by checking your weight using the Body Mass Index (BMI). Normal BMI ranges from 18.5 and 24.9. You can use handy BMI calculators online, so you won’t have to compute.
To shed those unwanted pounds, you should exercise regularly and eat a healthy diet. Healthcare providers recommend lessening your carbohydrate and sugar intake. And as a result, you should eat more fruits, vegetables, whole cereals, and lean meats. For a customized diet plan, consult your primary healthcare provider. Your underlying medical conditions may affect your physical activities. You should ask about this as well.
- Alternative or adjunct therapy: Lipotropic injections
These are fat-loss supplements. One of its derivatives is Lipostat. It has three components. First, Methionine prevents the build-up of excess fat in the liver and body. Second, Inositol is a nutrient that belongs to B complex vitamins. It helps in breaking down fats and reducing cholesterol. It also aids serotonin in regulating mood and appetite. Third, Choline supports liver health by getting rid of harmful chemical wastes in the body. It, too, helps metabolize cholesterol and fats. Often, the regimen adds Vitamin B-12 i to regulate your fat and boost your energy.
The main component Inositol makes Lipostat a promising therapy for PCOS. Johannes Joseph Scherer, a German physician in 1850, first saw Inositol in the muscle. It was first called muscle sugar. Later it was named Inositol with a Greek origin meaning carbohydrate inside a fiber. The most common form of this saturated compound is myo-Inositol (WebMD, n.d.). Found in plants as phytic acid, myo-Inositol improves glucose uptake, inhibits lipolysis, and increases insulin sensitivity (Kim et al., 2014). These benefits are the reason for using myo-Inositol for weight loss.
R.J. Anderson identified the structure of myo-Inositol in 1940 (Bizzarri, 2014). It regulates follicular stimulating hormone (FSH) and thyroid-stimulating hormone (TSH). FSH is essential in the development of ovaries and testes during puberty. On the other hand, TSH stimulates the production of hormones. Myo-Inositol also modulates sugar absorption. In 1988, Larner and colleagues revealed myo-Inositol and d-chiro-Inositol are chemical mediators of insulin (Bizzarri, 2014).
Inositol and folic acid
In 2007, a study conducted among 25 women who had scant or no menses found they had fewer chances of ovulating, which brought about their infertility. The researchers gave the women myo-Inositol with folic acid. Folate is a type of B vitamin. Folic acid, in a processed form, can be found in food and additives. It helps the body in maintaining or producing new cells.
After six months, 22 women started having their menstrual and ovulation periods. The good news, too, is that 10 of the women became pregnant. This study proved myo-Inositol with folic acid was safe and restored menstrual and ovarian functions (Papaleo et al., 2007).
Inositol and metformin
Inositol with metformin works well together also. Metformin decreases your blood sugar levels and helps in regulating insulin in your body. Twenty-seven women with PCOS who were overweight participated in a study. Nine used a diet only. Nine other women were given metformin with a diet. And the rest of the nine women were given myo-Inositol with diet. The researchers associated the weight loss with metformin and the regularity of the menstrual cycle with myo-Inositol (Le Donne et al., 2012).
Is Inositol Effective and Safe for PCOS?
Not everyone agrees Inositol has positive results. Researchers wrote a critical analysis of Inositol treatment. They based the review on a compilation of relevant MEDLINE studies about Inositol-based products used on women with PCOS. The researchers argued that the combination of myo-Inositol and di-chiro-Inositol counteracted each other (Roseff and Montenegro, 2020).
But, the growing body of evidence supports the efficacy of Inositol as a fat burner and therapy for PCOS. Inositol, may it be myo- or di-chiro, was effective and safe for women with PCOS, including those who underwent in-vitro fertilization procedures (Unfer et al., 2016). To this day, researchers continue to conduct further studies to either prove or disprove the capability of Inositol for PCOS.
Potential Side effects
Researchers also showed Inositolcombined with folic acid and metformin, in current studies, is effective. You may take these by mouth or injection. Both, though, have the potential for gastrointestinal discomforts. Inositol supplements have potential side effects such as nausea, gas, and stomach pain.
As an inotropic injection, Inositol goes directly into the body without having to pass through the stomach. The reaction of Inositol depends on the individual. Some may experience anxiety, dizziness, high blood pressure, or increased heart rate. A few may experience muscle problems or pain, such as myopathy. Myopathy manifests as muscle cramps, stiffness, weakness, or spasms. The risk is greater though in adults aged 65 years and older.
Other possible side effects of myo-Inositol include nausea, gas, diarrhea, and loose stools at 12 g/day or higher (Carlomagno and Unfer, 2011). The researchers also noted Inositol of 4 g/day is completely free of side effects. These are usually used in clinics. The Injection and Infusion Clinic of ABQ administers Lipostat/MIC as a fat burner injection at 1 ccs, 2 ccs, and 3 ccs, respectively.
- If you are pregnant, you should not take Lipostat, either as a supplement or injectable.
- Medical practitioners also caution people with diabetes, thyroid disorder, and kidney or liver disease.
- If you are allergic or hypersensitive, consult your healthcare clinician.
- People who consume alcoholic beverages of two or more servings per day are prohibited.
- Other medications you are taking may interact with Lipostat. Tell your primary healthcare provider about this before you start Lipostat therapy.
Are you convinced?
Lipostat/MIC burns fats and answers your fertility problems. You might want to know this inotropic injection has added benefits with its methionine and choline components.
For more information about Lipostat/MIC, please do not hesitate to visit or call us at the Injection and Infusion Clinic of ABQ – 505 445 4300.